1. Create two XML backup definitions. One to save the image of drive 'C' to 'E:\Images' and the other to save to 'F:\Images'. We'll call them 'Image to E.xml' and 'Image to F.xml'
    
2. Right click on 'Image to E' and select 'Generate a VBScript file'.
    
    
    
3. Accept all the defaults and click 'OK'.
    
4. Click the 'VBScript' tab, right click on the VBScript file and select 'Edit'
   
    
    
    
5. The file will now open in 'Notepad'. Turn of 'Word Wrap' to make editing easier...
    
   
    
    
6. Edit the file in notepad as follows:

Replace the line:

ExitCode = Backup ("""C:\Program Files\Macrium\Reflect\reflect.exe"" -e -w ""c:\users\nick\documents\reflect\Image to E.xml""")

With the following lines:

If DoesDirExist("E:\") = true Then
    ExitCode = Backup ("""C:\Program Files\Macrium\Reflect\reflect.exe"" -e -w ""c:\users\nick\documents\reflect\Image to E.xml""")
Else
    ExitCode = Backup ("""C:\Program Files\Macrium\Reflect\reflect.exe"" -e -w ""c:\users\nick\documents\reflect\Image to F.xml""")
End If

Note: Replace XML path and file names with the correct names for your scenario.

At the end of the VBScript source paste the following lines:

Function DoesDirExist(byVal pathname)
    Dim objFSO
    Set objFSO = CreateObject("Scripting.FileSystemObject")
    DoesDirExist = objFSO.FolderExists(pathname)
    Set objFSO = Nothing
End Function